After many years as an industry statistician, Susan joined FDA in 2018 and is now a Senior Mathematical Statistician reviewer in CDER, assigned to pulmonary, allergy and critical care indications. Susan’s interests in estimands, safety and benefit-risk assessment, and graphics have a common thread and focus: addressing the question of scientific interest, to make clear and precise decisions aligned with the clinical goals of the program by using structured thinking and framing during drug development and reporting, for the benefit of public health.