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06: PreClin Dev-EarlyPhaseCR [clear filter]
Monday, June 24

11:00am PDT

#113: Artificial Intelligence in Drug Discovery and Development: Emerging Technologies and Applications
Component Type: Forum
Level: Intermediate
CE: ACPE 1.00 Knowledge UAN: 0286-0000-19-527-L04-P; CME 1.00; IACET 1.00; RN 1.00

A discussion of advances in artificial intelligence and related technologies in computer, information and data science, specifically as they apply to challenges and emerging application areas within pre-clinical drug discovery and early drug development.

Learning Objectives

Describe translatable experiences and practices concerning impactful applications of artificial intelligence.


Scott Spangler, MA


Panelist: Activity Metabolomics and ArtificiaI Predictions
Erica Majumder, PhD

Challenges and Opportunities in Near-Term Quantum Computation
Yudong Cao, PhD, MS

Craig Lipset, MPH

avatar for Craig Lipset

Craig Lipset

Former Head of Clinical Innovation, Pfizer
Craig Lipset has led at the intersection of patient engagement, personal health data, and accelerating clinical research. He created and led Clinical Innovation at Pfizer, developing and scaling “first in industry” approaches to improving patient experience and innovative data... Read More →
avatar for Erica Majumber

Erica Majumber

Associate Director and Senior Safety Science Leader IIDO, Scripps Research
Dr. Majumder is a researcher with Dr. Gary Siuzdak in the Scripps Center for Metabolomics and Mass Spectrometry. Erica specializes in anaerobic metabolism and the activity of sulfur-containing metabolites. Recently, she has been spearheading their lab's new efforts using AI-based... Read More →

Yudong Cao

Co-founder and CTO, Zapata Computing
Yudong Cao is co-founder and CTO of Zapata Computing, a quantum software startup based in Cambridge, MA. His PhD thesis in Computer Science received 2016 Chorafas Award in Computer Science and Informatics. From 2016 to 2018 he worked as a postdoctoral researcher at Harvard University... Read More →

Scott Spangler

Distinguished Engineer, Chief Data Scientist for Life Sciences, IBM Watson
Scott Spangler is Chief Data Scientist, Distinguished Engineer, and Master Inventor in the Watson Health Life Sciences Group at the IBM Almaden Research Center. He has been doing knowledge base and data mining research for the past 25 years. Since coming to IBM in 1996, Scott has... Read More →

Monday June 24, 2019 11:00am - 12:00pm PDT
Room 2 San Diego Convention Center 111 W Harbor Drive, San Diego, CA 92101 USA
  06: PreClin Dev-EarlyPhaseCR, Forum
  • Featured Topics Artificial Intelligence,Innovative Trial Design,What's Next,Student Programming
  • Credit Type ACPE, CME, IACET, RN
  • Tags Forum

1:30pm PDT

#131 SB: On the Soapbox: Designing Babies - Medical, Ethical, and Social Questions
Component Type: Forum
Level: Intermediate
CE: ACPE 0.75 Knowledge UAN: 0286-0000-19-733-L04-P; CME 0.75; IACET 0.75; RN 0.75

New gene editing technology known as “clustered regularly interspaced short palindromic repeats” or CRISPR can alter the genes of cells, including embryos, changing the organism and its descendants, and raising critical ethical, legal, and social concerns. First discovered in 2014, scientists have rapidly used this technology in many species. This technique can also alter genes in microorganisms to create superbugs, and in 2016, the Pentagon listed it as a weapon of mass destruction. In 2018, a Chinese researcher stated that he had edited human embryos and transferred them into a womb, producing twin girls. Yet CRISPR can have ‘off-target’ effects, accidentally eliminating additional DNA, and genes may have multiple, unknown functions. In March 2019, scientists recommended a moratorium on transfer of altered embryos into wombs, and a registry of all CRISPR trials. Questions remain, however of how long such a moratorium should last, when it should end, who should decide, based on what criteria, whether all nations and researchers will agree, and what should be done if non-compliance occurs. Questions emerge of when CRISPR will be “safe enough” for initial research studies, and later for broader clinical use. The first human offspring may need to be followed through adulthood and the birth of their own children. This talk will explore these critical challenges, related to ethical principles of autonomy, risks, benefits and social justice, and how these questions might best be addressed.

Learning Objectives

Discuss the critical challenges related to ethical principles of autonomy, risks, benefits of gene editing technology.


Robert Klitzman, MD

avatar for Robert Klitzman

Robert Klitzman

Professor of Clinical Psychiatry; Director, Masters of Bioethics Program, Columbia University
Robert Klitzman, M.D., is a professor of psychiatry at the College of Physicians & Surgeons, & the Mailman School of Public Health, & the Director of the online and in-person Bioethics Masters & Certificate Programs at Columbia University. He has written over 130 scientific journal... Read More →

Monday June 24, 2019 1:30pm - 2:15pm PDT
Room 16AB San Diego Convention Center 111 W Harbor Drive, San Diego, CA 92101 USA
  06: PreClin Dev-EarlyPhaseCR, Forum
  • Featured Topics Precision Medicine
  • Credit Type ACPE, CME, IACET, RN
  • Tags Forum

3:30pm PDT

#162: Precision Medicines in Clinical Trials: Understanding and Overcoming Barriers to Adoption
Component Type: Forum
Level: Advanced
CE: ACPE 1.00 Knowledge UAN: 0286-0000-19-559-L04-P; CME 1.00; IACET 1.00; RN 1.00

Precision Medicines in Clinical Trials (PMCT) are demonstrably impactful in drug development yet are not widely adopted by industry. This forum explores reasons for low adoption from the viewpoints of scientists, drug developers and regulators and explores solutions.

Learning Objectives

Describe the value of precision medicine trials (PMCT) as an innovative approach to drug development; Identify the regulatory, scientific, operational and technical challenges and barriers to the execution of these trials.; Explain key considerations for precision medicine trial design and execution.


Anita Nelsen


Academic Perspective from Korea
Yeul Hong Kim, MD, PhD

Edward Abrahams, PhD

Rebecca Blanchard, PhD

avatar for Edward Abrahams

Edward Abrahams

President, Personalized Medicine Coalition
Edward Abrahams, Ph.D., is the President of the Personalized Medicine Coalition. Representing innovators, scientists, patients, providers and payers, PMC promotes the understanding and adoption of personalized medicine concepts, services and products for the benefit of patients and... Read More →
avatar for Rebecca Blanchard

Rebecca Blanchard

Vice President, CRISPR Therapeutics
Dr. Blanchard’s career in academia and industry has spanned basic, translational, and clinical research. She is currently responsible for Clinical Biomarkers and Exploratory Research, Assay Development and Pharmacology/Toxicology at CRISPR Therapeutics. After receiving her Ph.D... Read More →
avatar for Yeul Hong Kim

Yeul Hong Kim

Professor, Section of Medical Oncology, Department of Internal Medicine, Korea University Anam Hospital
Yeul Hong Kim, MD, PhD, is a Professor in the Department of Internal Medicine at the Korea University College of Medicine in Seoul. He is actively involved in cancer genomic research, using circulating tumor DNA, for lung and gastrointestinal cancers. His primary area of interest... Read More →
avatar for Anita Nelsen

Anita Nelsen

Senior Vice President, Translational Medicine, Parexel
Anita is a pharmaceutical industry leader who has applied pharmacogenetic, human and molecular genetics research in drug discovery and development. As Head of Translational Medicine, Anita leads a global team of scientists who are recognized thought leaders and influencers in quantitative... Read More →

Monday June 24, 2019 3:30pm - 4:30pm PDT
Room 2 San Diego Convention Center 111 W Harbor Drive, San Diego, CA 92101 USA
  06: PreClin Dev-EarlyPhaseCR, Forum |   02: ClinTrials -ClinOps, Forum
  • Level Intermediate
  • Featured Topics Artificial Intelligence,Regulator Thinking,Innovative Trial Design
  • Credit Type ACPE, CME, IACET, RN
  • Tags Forum
Tuesday, June 25

4:15pm PDT

#290: The Responsibility Industry, Agencies, and Early Education own in Cure-Model Based Therapeutics
Component Type: Forum
Level: Intermediate
CE: ACPE 1.25 Knowledge UAN: 0286-0000-19-632-L04-P; CME 1.25; IACET 1.25; RN 1.25

In today’s pharmaceutical and biotech industry we are at an inflection point with regard to the future of therapeutic development. In this forum the focus will be to explore how industry, agencies, and academic institutions collaborate to drive innovative technologies to speed therapeutic development. Specifically, the forum will explore how we are leveraging STEM (Science, Technology, Engineering, Mathematics) programs both independently and interactively to enable current and future entrepreneurial opportunities. The goal is to foster an environment where we best take advantage of the opportunities presented by advances in life sciences and technology.

Learning Objectives

Evaluate the quality of interaction among various stakeholders in cure-based drug development; Assess the quality of those interactions in their own environments; Recognize the importance of fostering an environment where creativity and an entrepreneurial spirit is nurtured. Determine how STEM (Science, Technology, Engineering, Mathematics) programs are put to use to address the aforementioned objectives.


Dan Tierno, MA, MBA


Industry Perspective
Yaron Drucker, MBA

Student Perspective
Advaita Chandramohan

Melanie Matheu, PhD


Advaita Chandramohan

Undergraduate Research Associate, University of Southern California
Advaita Chandramohan is a second year student at the University of Southern California studying Biomedical Engineering with an Electrical emphasis. Throughout her academic career, Advaita has participated in and led various STEM activities, leading to her continued interest in the... Read More →
avatar for Yaron Drucker

Yaron Drucker

Staffing Lead, Cloud Partners, Google
Yaron has a Bachelor's Degree in Electrical Engineering, and an MBA from Baruch College. In his early career, Yaron worked in aerospace and defense as an EMC/EMI Engineer, and at SAP for a year. He then worked at Microsoft for 7 years in various roles in digital media on the advertising... Read More →
avatar for Dan Tierno

Dan Tierno

Associate Director, Global Clinical Data Sciences and Analytics, Bayer
Mr. Dan Tierno has over 20 years of experience in the pharmaceutical and biotech industry, specializing in drug development, data sciences and analytics for clinical trials, and commercialization of novel small molecule and cell based therapeutics. Mr. Tierno has spoken on training... Read More →

Melanie Matheu

Founder and Chief Executive Officer, Prellis Biologics, Inc.

Tuesday June 25, 2019 4:15pm - 5:30pm PDT
Room 16AB San Diego Convention Center 111 W Harbor Drive, San Diego, CA 92101 USA