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Tuesday, June 25 • 8:00am - 9:15am
#209: Emerging Issues in CRISPR and Gene Editing Symposium

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Component Type: Session
Level: Intermediate
CE: ACPE 1.25 Knowledge UAN: 0286-0000-19-577-L04-P; CME 1.25; IACET 1.25; RN 1.25

This session will discuss emerging issues related to gene editing, including standards for off-target effects, immunogenicity issues , and DNA base editors.

Learning Objectives

Describe potential concerns related to immune responses in gene editing; Discuss the concept of on-target and off-target genome editing, and collaborative approaches to address this issue; Identify the difference between gene editing that involves making a double-stranded break in DNA versus DNA base editors that do not.

Chair

Philip (P.J.) Brooks, PhD

Speaker

Immunogenicity Issues Related to Gene Editing
Zuben Erach Sauna, PhD

Update on the Genome Editing Consortium
Samantha Maragh, PhD, MS

Base Editing: Performing Chemsitry on the Genome
Alexis C Komor, PhD


Speakers
avatar for Philip (P.J.) Brooks

Philip (P.J.) Brooks

Program Director, Office of Rare Diseases Research, National Center for Advancing Translational Sciences (NCATS), NIH
Philip John (P.J.) Brooks is a Program Director in the NCATS Office of Rare Diseases Research. He is also the Working Group Coordinator for the NIH Common Fund program on Somatic Cell Genome Editing. He earned his Ph.D. in neurobiology from the University of North Carolina at Chapel... Read More →
avatar for Zuben Sauna

Zuben Sauna

Principal Investigator, OTAT, CBER, FDA
Zuben E. Sauna is a Principal Investigator and also a CMC Reviewer at the US Food and Drug Administration. His research interests lie in understanding the pharmacogenetic basis of the immune response to proteins used in therapeutic interventions as these affect efficacy and safety... Read More →
avatar for Alexis Komor

Alexis Komor

Assistant Professor, University of California San Diego
Alexis Komor received her B. S. degree in chemistry from UC Berkeley in December 2008. She then joined the lab of Jacqueline K. Barton at Caltech where she worked on the design, synthesis, and study of DNA mismatch-binding metal complexes and received her Ph.D. in 2014. She pursued... Read More →
avatar for Samantha Maragh

Samantha Maragh

Leader, Genome Editing Program, NIST
Dr. Samantha Maragh Leads the Genome Editing Program at the National Institute of Standards and Technology (NIST). Included in this program is the newly launched NIST Genome Editing Consortium, a public-private partnership to bring together government, industry and academia to address... Read More →

Tuesday June 25, 2019 8:00am - 9:15am
Room 2 San Diego Convention Center 111 W Harbor Drive, San Diego, CA 92101 USA
  06: PreClin Dev-EarlyPhaseCR, Session